Explore Corrective and Preventive Action (CAPA) in the pharmaceutical industry', its process, benefits, CA vs. PA, key elements, case studies, and its role in continuous improvement
Read MoreDeveloping a Gas Chromatography (GC) method is a systematic process that requires a deep understanding of both the analytical technique and the sample’s characteristics. Here’s a clear, step-by-step approach to developing an effective GC method GC Method Development GC Method Development is the systematic process of selecting and optimising the appropriate chromatographic conditions, including the […]
Read MoreHPLC column, working principles, types, expert tips for optimal use, and effective cleaning and regeneration procedure
Read MoreLearn how to prepare and optimise HPLC mobile phases correctly with expert tips, cost-saving strategies, and real case studies
Read MoreAnalysing non-volatile compounds with GC using Derivatisation
Read MoreLearn HPLC method development from a chromatography expert with 30 years of experience. Includes practical tips, case studies, and FAQs
Read MoreLearn HPLC detector, types, selection procedure, expert tips with case study studies and FAQs
Read MoreLearn everything about GC column, including types, how to select the right one, real-world case studies, and answers to frequently asked questions
Read MoreLearn how the Biopharmaceutics Classification System (BCS) classifies drugs based on solubility and permeability to predict oral drug absorption, bioavailability, and guide formulation development
Read MoreLearn about column efficiency in HPLC and GC, including its calculation, role in chromatographic methods, and acceptance criteria for optimal system performance
Read MoreIn HPLC, void volume refers to the volume within the column that is not occupied by stationary phase particles but is instead filled with the mobile phase. Dwell volume (also known as gradient delay volume and denoted as Vá´…) is the volume of mobile phase between the solvent mixing point and the column inlet in […]
Read MoreLearn what resolution in HPLC means, how it’s calculated, key factors affecting it, and its role in method development and system suitability testing
Read MoreExplore Liquid Chromatography Mass Spectrometry (LCMS) in pharmaceutical development - learn structure elucidation, ionisation modes, mass analyser, and expert tips with real-world case studies
Read MoreUnderstand the role of capacity factor in HPLC, including how to calculate it, why it matters in method development, and what affects its value for optimal chromatographic results
Read MoreLearn the importance of System Suitability Testing (SST) in chromatography for HPLC, GC, LCMS, and more. Discover how to establish SST criteria, evaluate system performance, and avoid common pitfalls during method development.
Read MoreLearn about the tailing factor in HPLC and GC, including its calculation, significance in method development, acceptance criteria, and key factors affecting peak symmetry in chromatographic analysis.
Read MoreLearn about HETP (Height equivalent to a theoretical plate). Explore its definition, calculation formula, influencing factors, applications, and real-world case studies to optimize column efficiency
Read MoreLearn the importance of photostability testing in pharmaceuticals, including procedures, benefits, case studies, and how it ensures drug safety, quality, and efficacy
Read MoreDiscover the importance of forced degradation studies in pharmaceutical development, including procedures, condition selection, impurity identification, and analytical strategies
Read MoreUnderstand the importance of Detection Limit (DL) and Quantification Limit (QL) in analytical method validation. Learn definitions, regulatory guidelines, and how to determine DL and QL in pharmaceutical analysis.
Read MoreLearn how to evaluate linearity and range in method validation with step-by-step procedures, a real-life case study, and answers to common FAQs. Gain the confidence to perform the test independently.
Read MoreExplore the importance of robustness in analytical method validation with practical guidance, a case study, and FAQs to help you perform the test effectively and efficiently
Read MoreLearn the importance of solution stability in analytical method validation with a practical case study. Understand why and how this test is performed, and gain the skills to apply it independently
Read MoreLearn Recovery Calculation In Analytical Method Validation with a step-by-step guide, real case study, and answers to common FAQs. Essential for accurate and reliable method development
Read MoreAccuracy in Analytical Method Validation is one of the most critical parameters, directly impacting the reliability and credibility of test results. It ensures that the method measures exactly what it is intended to, without bias or error. In this article, we will explore how to perform accuracy testing in analytical method validation, supported by step-by-step […]
Read MoreLearn the complete procedure for evaluating precision in method validation, including system precision, method precision, reproducibility, and intermediate precision with real-world case studies
Read MoreLearn how to evaluate specificity during analytical method validation in pharmaceutical analysis. Includes step-by-step procedures, acceptance criteria, case study, and FAQs.
Read MoreLearn Analytical Method Validation (AMV) step by step with clear guidelines, key parameters, classifications, and expert strategies. A must-read for pharma QA/QC professionals
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Understand potency, purity, and assay in pharma testing. Discover key differences, how to calculate them, and why they matter in drug development
Read MoreExplore expert insights on nitrosamine impurities in pharmaceuticals, including their toxicity, formation during manufacturing, detection challenges, and effective control strategies. Learn through case studies and FAQs
Read MoreThe Relative Response Factor (RRF) is defined as the ratio between the Response Factor of the impurity and the Response Factor of the main analyte standard. In pharmaceutical analysis, ensuring the quality and purity of Active Pharmaceutical Ingredients (APIs) is of paramount importance. This quality is often determined by analysing the impurity profile, which requires […]
Read MoreLearn the key differences between Analytical Method Validation and Verification in pharmaceutical analysis. Explore their applications, advantages, and case studies to gain practical insights into these essential processes
Read MoreExplore effective control of impurities in pharmaceuticals, covering sources, types, challenges, and regulatory guidelines. Learn advanced analytical techniques and real-world case studies to enhance drug quality, safety, and efficacy
Read MoreDiscover various methods to determine pKa values, including titration, UV-Vis spectroscopy, NMR, HPLC, and the Henderson-Hasselbalch equation. Learn the principles, procedures, and applications of each technique for accurate pKa determination.
Read MoreExplore the importance of solubility in drug development, bioequivalence, and quality control. Learn about solubility principles, classification, calculation by HPLC, and factors affecting solubility. Dive into pharmaceutical solvent selection, case studies, and FAQs to enhance your understanding."
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This article describes Genotoxicity and Mutagenicity, chemistry behind genotoxicity and mutagenicity and structure alert concept to identifying genotoxins
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The chromatographic peaks that do not belong to the sample matrix or diluent and whose origin is unknown are called ghost peaks.
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This article describes equivalent HPLC columns, steps for selection of equivalent column with case studies and FAQs
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The specified and unspecified Impurities play a vital role in the related substance or impurities profile specification of any pharmaceutical. Both specified and unspecified Impurities refer to the identification, control, and regulation of these impurities during drug development and manufacturing.
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HPTLC is a modified and advanced version of the TLC technique. It is a powerful analytical technique that provides a highly sensitive, reproducible, and cost-effective means of separating, identifying, and quantifying components in a mixture.
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ICPMS is an advanced analytical technique widely used in pharmaceutical development for detecting trace metals, including both essential and potentially harmful elements, at very low concentrations. Its high sensitivity and precision make it invaluable in a range of applications, from raw material testing to quality control of final APIs (Active pharmaceutical ingredients).
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