Description

Chiral Method Development | Foundation Course | Course Description

The Chiral Method Development | Foundation Course by PharmaGuru is designed to introduce learners to the fundamentals of chiral separation techniques used in pharmaceutical analysis. Chirality plays a critical role in drug safety and efficacy, as enantiomers of a compound can exhibit significantly different biological activities.

This beginner-level course focuses on the principles of chiral chemistry, selection of chiral stationary phases, and method development strategies using techniques such as HPLC and GC. Learners will gain practical insights into resolving enantiomers, optimizing separation conditions, and understanding regulatory expectations for chiral analysis in the pharmaceutical industry.

The course is ideal for students, fresh graduates, and professionals seeking to build a strong foundation in analytical research, quality control, and method development.

Key Learnings

• Achiral and Chiral Molecules explanation with examples
• Thalidomide tragedy and Chirality
• Stereochemistry, optically active molecules, Enantiomers, Diastereomers, Racemate/Racemic mixture explanation with case studies
• Optical isomers calculation formula,
• A birds eye views on Chiral stationary phases
• Polysaccharide derived (Coated and immoblised Chiral stationary phase) chemistry
• Classification of Polysaccharide derived CSP
• Polysaccharide derived Chiral Stationary phase selection with case studies
• Forces responsible for Chiral separation with case studies
• Factors affecting Separation mechanism
• Basics of method optimization and resolution improvement
• Chiral Method Development strategy
• Troubleshooting common issues in chiral separations
• How to start chiral method development | Two steps process
• Chiral Separation using Normal phase chiral chromatography: Selection of mobile phase, selection of stationary phase, Chiral method development containing one and 2 chiral centres, Case studies: Neutral compound, Basic Molecule, and Acidic molecule
• Chiral Separation using Normal phase chiral chromatography: Sample characterisation, Mobile Phase Selection, Case study: Basic compound, acidic compounds & non polar compounds
• Advantages and Limitations and Top Interview Questions with answers On Chiral Separation

Note:
Reading tutorial will be provided after training
Test will be conducted and certificate will be provided