Gas Chromatography (GC) in Drug Development: Techniques, Case Studies, and Expert Tips - PharmaGuru

Q: What is the Principle of GC?

The principle of GC is partitioning : compounds are separated based on their relative affinities between a stationary phase (inside a column) and a mobile phase (carrier gas) . Components with lower boiling points or weaker interaction with the stationary phase elute faster.

Q: What are the Different Types of GC?

There are two types of GC: 1. Gas–Liquid Chromatography (GLC): Uses a liquid-coated stationary phase (most common). 2. Gas–Solid Chromatography (GSC): Uses a solid stationary phase.

Q: What are the advantages of GC?

1. Fast and accurate 2. Good for quantitative and qualitative analysis 3. High efficiency and resolution 4. Requires small sample volumes

Question 1

What is Gas Chromatography (GC)?

Accepted Answer

GC is a technique used to separate and analyse volatile and semi-volatile compounds in a mixture based on their distribution between a stationary phase and a mobile gas phase.

Question 2

What is the Principle of GC?

Accepted Answer

The principle of GC is partitioning: compounds are separated based on their relative affinities between a stationary phase (inside a column) and a mobile phase (carrier gas). Components with lower boiling points or weaker interaction with the stationary phase elute faster.

Question 3

What are the Different Types of GC?

Accepted Answer

There are two types of GC:
1. Gas–Liquid Chromatography (GLC): Uses a liquid-coated stationary phase (most common).
2. Gas–Solid Chromatography (GSC): Uses a solid stationary phase.

Question 4

What are the advantages of GC?

Accepted Answer

1. Fast and accurate
2. Good for quantitative and qualitative analysis
3. High efficiency and resolution
4. Requires small sample volumes

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By Dr Pramod Kumar Pandey - June 9, 2025

Protected: Gas Chromatography (GC) in Drug Development: Techniques, Case Studies, and Expert Tips

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