GC Troubleshooting: 7+ Common Problems and Their Solution
GC troubleshooting involves identifying and resolving common problems that can affect peak shape, retention time, resolution, sensitivity, and reproducibility GC systems can experience performance issues that affect accuracy, precision, and efficiency. In this article, I will discuss quick identification and resolution of these problems to ensure reliable results and minimise downtime GC Troubleshooting The process […]
What is GC Bleeding And How It Affect GC Analysis
GC bleeding, also known as GC column bleed, occurs when the stationary phase thermally degrades at temperatures near the column’s upper limit, leading to unwanted baseline noise or artefacts. GC bleeding can reduce the quality, damage the detectors, and increase the analysis costs. In this post, we’ll break down what GC bleeding is, why it […]
Reverse Phase And Normal Phase HPLC: Why Reverse Phase Is More Common
Reverse Phase and Normal Phase HPLC are widely used in pharmaceutical development, still Reverse-Phase HPLC (RP-HPLC) is preferred over Normal-Phase HPLC (NP-HPLC) due to its better compatibility, broader analyte range, simpler method development, and easier system stabilisation. Reverse Phase And Normal Phase HPLC: Why Reverse Phase Is More Common? The following 6 main key reasons explain […]
Tailing and Fronting in HPLC And GC: 7 Causes and Expert Tips to Reduce Them
Learn causes peak tailing and fronting in HPLC, and procedure to reduce them with FAQs
Pharmaceutical Analysis: Tips to Reduce Cost Without Compromising Quality
Pharmaceutical analysis is a significant contributor to the overall cost of drug development and manufacturing. For companies striving to stay competitive while adhering to stringent regulatory requirements, the challenge is clear: how do you reduce the cost of pharmaceutical analysis without compromising quality? Pharmaceutical Analysis: Tips to Reduce Cost Without Compromising Quality Pharmaceutical analysis plays […]
Why Is Starch Added at the End of an Iodometric Titration
In Iodometric Titration, starch gives a water-insoluble complex with iodine. This water-insoluble complex creates problems in detecting the actual endpoint. This means that the endpoint appears before the actual endpoint. That is why the starch indicator is added just before the end point when the colour is pale-straw yellow. In analytical chemistry, iodometric titration stands […]
HPLC Water: How to Decide fate Of HPLC Analysis
Learn how to select, store, and handle HPLC-grade water to improve chromatographic performance. Discover best practices that ensure cleaner baselines, longer column life, and more reliable HPLC results.
12 Easy Steps to Reduce HPLC Method Development Cost
Learn to reduce HPLC method development cost in 12 easy steps.
DQ, IQ, OQ, And PQ: Concept, Applications and FAQs
Learn DQ, IQ, OQ, And PQ: Concept with applications, case studies and FAQs
HPLC Troubleshooting: 5+ Common Problems and Their Solutions
HPLC troubleshooting is the process of identifying common HPLC problems, their possible causes, and providing practical solutions to these problems to ensure reliable results and minimise downtime. High-Performance Liquid Chromatography (HPLC) is a powerful analytical technique used widely in pharmaceutical development and several other industries. However, like any complex instrument, HPLC systems can experience performance […]