How to handle or destroy the nitrosamine impurities after its expiry and its analytical waste?
The chemical degradation methods can be used for lab-scale handling and destruction of nitrosamine waste. But keep in mind any nitrosamine waste, chemical treatment is supplementary only—final disposal must still be through a licensed hazardous-waste contractor and in full compliance with local and international regulations. Acidic Hydrolysis: Strong acid/acetic acid systems are known to cleave […]
During RS Method Development how can designed known and Unknown impurity limit
The Relative Response Factor (RRF) represents the ratio of the detector responses of equal amounts of an impurity and the drug substance. In the United States Pharmacopoeia (USP), RRF is referred to as Response Factor (RF), or Relative Response Factor (RRF), and is denoted as F. In contrast, the European Pharmacopoeia (Ph. Eur.) refers to […]
What is HPLC?
High-pressure/high-performance liquid chromatography is a separation technique based on solid stationary and liquid mobile phases. Separations depend upon the polarity of the stationary phase, mobile phase and molecules. Separation may be achieved by either the Partition mechanism or the Adsorption mechanism
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