How To Decide Tailing Factor Limit In HPLC And GC Analysis: Get Mastery In 3 Minutes - PharmaGuru

Q: What is HPLC peak tailing?

A tailing peak in chromatography refers to a peak where the descending part (the "tail") extends more slowly than the ascending part. It causes asymmetry , making the peak skewed to the right .

Question 1

What is tailing in chromatography

Accepted Answer

The tailing factor tells about the symmetry of the chromatographic peak

Question 2

What is tailing factor in HPLC?

Accepted Answer

The tailing factor tells about the symmetry of the peak in HPLC analysis

Question 3

What is USP tailing factor limit?

Accepted Answer

USP tailing factor indicates whether a peak is tailing (longer at the back) or fronting (longer at the front). A tailing peak has a front greater than 1.0, while a fronting peak has a front less than 1.0.

Question 4

What is USP  tailing factor?

Accepted Answer

The USP tailing factor tells about the symmetry of the peak in HPLC analysis

Question 5

What is the tailing factor formula?

Accepted Answer

Tailing factor (T)=(X+Y)/2,  where X is the front half width and Y is the back half width at 5% of the peak height

Question 6

What is HPLC peak tailing?

Accepted Answer

A tailing peak in chromatography refers to a peak where the descending part (the "tail") extends more slowly than the ascending part. It causes asymmetry, making the peak skewed to the right.

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By Dr Pramod Kumar Pandey - May 4, 2025

Protected: How To Decide Tailing Factor Limit In HPLC And GC Analysis: Get Mastery In 3 Minutes

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